Ms Palaszczuk said the State Government would reassess the situation on May 15 and that, if everything went to plan, all students would return to classrooms from May 25.
The Premier said the plan was subject to change if there was an increase in coronavirus cases, or any new cases of community transmission or localised outbreaks.
State Education Minister Grace Grace said it was essential for anyone who was unwell to stay away from schools.
"If low transmission rates continue, students from years 2 to 10 will be able return from May 25," Ms Grace said. She said the reopening would be subject to an ongoing ban on large school gatherings such as assemblies or excursions.